Mohd Azlan, Nur Hazirah (2018) A Systematic Review Of Targeted Titanium Dioxide Nanoparticles For Cancer Theraрy. Masters thesis, Universiti Sains Malaysia.
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Abstract
Titanium dioxide nanoparticles (nano-TiO2) provides promising application as targeted cancer therapeutics. Further understanding on the toxicity guidelines and ideal physiochemical properties are crucial for efficient clinical application. This study provides an updated review on nano-TiO2 as nanotherapeutics focusing on the modification of physiochemical properties, potential routes of administration, biodistribution, clearance and toxicity profile. The review conducted is based on PRISMA-P protocol. It began with literature searching from selected databases; PubMed, Springer Link, Science Direct and general search engine Google Scholar based on the pre-determined keywords (titanium dioxide nanoparticles, targeted drug delivery, targeted cancer therapy, surface modification, delivery route, route of administration).The search generated 873 manuscripts. We included all pre-clinical and clinical studies, original and in-press articles published within the past 6 years (2013 till 2018). Studies involving usage of organic nanoparticles, and those in predatory or blacklisted journals were excluded. Selected studies underwent thorough appraisal yielded 61 articles that answered the research questions and met the inclusion and exclusion criteria. Results suggested that nano-TiO2 can be considered an ideal candidate for cancer nanotherapuetics. Surface modification of nano-TiO2 with different ligands enhanced the treatment efficacy and minimize the adverse effects that current cancer treatment might cause. Delivery of nanoTiO2 in human as targeted cancer therapy through different routes seems promising and require further exploration and research on this issue. Review summarized that,biodistribution, cleranace and toxicity risk of nano-TiO2 can be tackeld by modulating their physio-chemical properties. Future studies should be directed towards discovering actual potential of nano-TiO2 for cancer therapeutics which may indeed encourage its clinical application in near future.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine |
| Divisions: | Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis |
| Depositing User: | NOR HASHIMY BIN ABDULLAH |
| Date Deposited: | 15 Jul 2026 01:55 |
| Last Modified: | 15 Jul 2026 01:58 |
| URI: | http://eprints.usm.my/id/eprint/64634 |
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