Susceptibility patterns, resistance genes, risk factors and outcomes of multidrug-resistant pseudomonas aeruginosa in northeastern state of Malaysia: A multicenter study

Salim, Siti Norfairuz Md (2022) Susceptibility patterns, resistance genes, risk factors and outcomes of multidrug-resistant pseudomonas aeruginosa in northeastern state of Malaysia: A multicenter study. Masters thesis, Universiti Sains Malaysia.

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Abstract

Background: Multi-drug resistant Pseudomonas aeruginosa (MDR-PA) is one of the emerging nosocomial Gram-negative organisms responsible for high morbidity and mortality. Gradual increase in antibiotic resistance left clinician with limited therapeutic options. Minimal data exist regarding MDR-PA in Malaysia. Therefore, this study aimed to investigate the common resistance genes, activity of ceftolozane-tazobactam (C-T), risk factors and outcomes of MDR-PA infection. Methodology: In this case-control study, two hundred subjects were recruited from four major hospitals in Kelantan State of Malaysia between March 2021 and February 2022. One hundred MDR-PA isolates were subjected to antimicrobial susceptibility tests and resistance gene detections. Whereas risk factors and outcomes were analysed by comparing 1:1 case (MDR-PA) and control (susceptible-PA). Result: The new antibiotic, ceftolozane-tazobactam activity showed the best performance among β-lactams (53.0% of MDR-PA were resistant). The most prevalent gene was OprD (91.0%) and followed by bla-NDM-1 (46.0%). None of the isolates carry bla-OXA-48 gene. The factors independently associated with MDR-PA acquisitions were age The emergence of Pseudomonas aeruginosa harbouring bla-NDM1 gene in Kelantan state population should alarm clinicians since it can spread from person to person, causing outbreaks. Early anticipation in patient at risk of acquiring MDR-PA is crucial to facilitate case detection and infection control measures

Item Type: Thesis (Masters)
Uncontrolled Keywords: Multi-drug resistant Pseudomonas aeruginosa
Subjects: Q Science > QR Microbiology
R Medicine
Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Thesis
Depositing User: MUHAMMAD AKIF AIMAN AB SHUKOR
Date Deposited: 14 Jul 2026 02:08
Last Modified: 06 Oct 2026 07:48
URI: http://eprints.usm.my/id/eprint/64629

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