Adzaludin, Noor Sheereen (2019) Rate And Predictors For Red Cell Alloimmunisation In Tranfusion Dependent Thalassaemic Children In Hospital Kuala Lumpur. Masters thesis, Universiti Sains Malaysia.
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Abstract
Introduction Transfusion dependent thalassaemia patients have an overall increased risk towards red cell alloimmunisation. Many predictors may be associated with alloantibody development. Thus, this study was conducted to determine the rate and predictive factors for red cell alloimmunisation development as well as to compare the rate of alloimmunisation before and after providing phenotype matched blood transfusion policy in transfusion dependent thalassaemic children in HKL. Method This retrospective cohort study recruited a total of 44 patients. They were grouped into two groups. Standard matched (SM) group was for those diagnosed before July 2014, and those who were diagnosed after July 2014 were grouped into phenotype matched (PM) group. All clinical information were obtained from the patients' clinical case notes, whereas the transfusion information from PDN. The data includes patients' demographic information, transfusion exposure and alloimmunisation status. These data were then analysed using the Statistical Package for Social Sciences (SPSS) software. Result Out of 44 patients, 5 (11.4%) subjects were alloimmunised, 4 (18.2%) from SM and 1 (4.5%) from PM group. The commonest alloantibody was anti-E, 3 out of 5 alloimmunised subjects. There was no significant difference in the overall rate of alloimmunisation between the SM and PM group. There was also no significant association between the predictors explored with the rate of alloimmunisation in these patients. Conclusion: This study concludes that after the implementation of antigen matched phenotype transfusion policy, the rate of alloimmunisation showed a large numerical reduction despite the fact that there was no statistical significance.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine |
| Divisions: | Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis |
| Depositing User: | NOR HASHIMY BIN ABDULLAH |
| Date Deposited: | 14 Jul 2026 02:05 |
| Last Modified: | 14 Jul 2026 02:05 |
| URI: | http://eprints.usm.my/id/eprint/64628 |
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