Hamid, Auni Fatin Abdul (2025) Roles Of Lipids And Lipoprotein Metabolism In The Mechanism Of Drug-Resistant In Different Subtypes Of Breast Cancer. PhD thesis, Perpustakaan Hamzah Sendut.
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Abstract
Breast cancer is the second most common cancer worldwide and a leading cause of cancer-related mortality in women. Obesity, often accompanied by elevated circulating lipids and lipoproteins, is increasingly recognised as a factor that worsens disease progression and therapy response. In this lipid-rich environment, cancer cells gain access to abundant substrates that can be exploited to support growth, survival and adaptation under therapeutic stress. However, the mechanisms by which obesity-associated metabolic dysregulation promotes lipoprotein utilisation and contributes to therapy resistance remain unclear. This study aims to investigate the roles of oxidised low-density lipoprotein (oxldl) and very low-density lipoprotein (vldl) in drug resistance and lipid metabolic reprogramming across different breast cancer subtypes, by characterising resistant cell models and examining their effects on cell viability, gene expression regulation, metastatic behaviour and targeted gene knockdown. Drug-resistant models were established by developing tamoxifen-resistant mcf-7 (mcf-7-tamr) and paclitaxel-resistant mda-mb-231 (mda-mb-231-pacr) cells through stepwise drug exposure and pulsed treatment, respectively.
| Item Type: | Thesis (PhD) |
|---|---|
| Subjects: | R Medicine > R Medicine (General) > R5-920 Medicine (General) |
| Divisions: | Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis |
| Depositing User: | Mr Hasmizar Mansor |
| Date Deposited: | 26 Jun 2026 01:24 |
| Last Modified: | 26 Jun 2026 01:24 |
| URI: | http://eprints.usm.my/id/eprint/64486 |
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