Anti-cancer And Anti-angiogenic Activities Of Natural Compound Zerumbone From Zingiber Zerumbet - A Systematic Review

Elfagie, Rehab M. H. (2019) Anti-cancer And Anti-angiogenic Activities Of Natural Compound Zerumbone From Zingiber Zerumbet - A Systematic Review. Masters thesis, Universiti Sains Malaysia.

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Abstract

Significant number ofliterature has demonstrated the anti proliferative effect of Zerumbone and its role as anti-angiogenesis. The aims of this systematic review were to evaluate the anti-cancer effects of Zerumbone and the role of its antiangiogenic properties in treating cancer. Relevant articles were selected based on specific inclusion criteria. Articles chosen for this systematic review were between January 2008 and December 2018. Relevant articles were identified through an extensive search in Science Direct, PubMed, Google Scholar and Scopus. The literature searches of the electronic databases combined the following key words: anti-angiogenic, anticancer, Zerumbone and Zingiber zerumbet. Studies chosen for this review includes the following designs in vitro, in vivo and ex vivo. The initial literature search obtained a total of 352 related records and the final number of studies that met the inclusion criteria in the current review was 43 studies. In vitro studies was the commonest study design. Evidently, Zerumbone demonstrate a potential antiproliferative and antiangiogenic. The anti proliferative activities of Zerumbone was shown to induce by different signalling pathway.Zerumbone through its antiangiogenic effect play a great role in reducing invasion and metastasis. Some selected studies on Zerumbone were found to plague with limitation such as lack of toxic threshold value which may be needed for the clinical trials on this compound.

Item Type: Thesis (Masters)
Subjects: R Medicine
Divisions: Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis
Depositing User: NOR HASHIMY BIN ABDULLAH
Date Deposited: 25 Jun 2026 05:10
Last Modified: 25 Jun 2026 05:10
URI: http://eprints.usm.my/id/eprint/64455

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