Yusuf, Nur Fatihah (2019) Association Between Tumor-infiltrating Lymphocytes And Pd-ll Expression In Human Invasive Breast Ductal Carcinoma, Nst. Masters thesis, Universiti Sains Malaysia.
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Abstract
Introduction: Breast cancer is the second common cancer diagnosed after lung cancer. It is the commonest cause of cancer-related mortality among women. Several lines of evidence link the roles of tumor infiltrating lymphocytes and PD-Ll expression with host antitumor immunity. This study aims to investigate the association among tumorinfiltrating lymphocytes, PD-Ll and clinicopathological parameters in invasive breast ductal carcinoma. Methods: A total of 80 cases of breast cancer from year 2016 to 2018 were utilized to investigate the presence of tumor-infiltrating lymphocytes. Relevant clinicopathological information was extracted. lmmunohistochemistry methods were used to investigate the expression of PD-Ll in 67 breast cancer tissue section. The association between tumor infiltrating lymphocytes, PD-Ll expression and clinicopathological parameters were analysed. Results: Over half of the patients were over 40 years of age. Majority of the patients were Malays. In addition, 42.5% of cases were classified as lymphocyte predominant breast cancer (score 2'.:50 %). Tumor-infiltrating lymphocytes had a significant association with tumor grades, ER receptor status, PR receptor status and Ki-67 index. The expression of PD-LI in tumor area was shown in 22of67 cases and 28of67 cases in stromal area. PD-L 1 was significantly associated with higher tumor grades and higher levels of tumor infiltrating-lymphocytes. Conclusion: Tumor infiltrating lymphocytes and PD-Ll expression is an important indicator of immunological imbalance and they are associated with unfavourable characteristic of breast cancer.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine |
| Divisions: | Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis |
| Depositing User: | NOR HASHIMY BIN ABDULLAH |
| Date Deposited: | 25 Jun 2026 02:55 |
| Last Modified: | 25 Jun 2026 02:55 |
| URI: | http://eprints.usm.my/id/eprint/64451 |
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