Rajasegaran, Rajayaashini (2025) Elucidating The Molecular Pathways Of Cellular Senescence Via S-Phase Kinase Associated Protein 2 Gene Suppression In Acute Myeloid Leukemia Cell Lines. PhD thesis, Perpustakaan Hamzah Sendut.
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Abstract
Acute myeloid leukemia (aml) is a type of hematological malignancy characterized by clonal expansion of myeloid progenitors that primarily occurs in bone marrow and/or peripheral blood. Aml represents a significant global health issue that warrants attention due to its contribution to overall disease burden. In accordance with this, contemporary studies suggest that cellular senescence could function as a tumour suppressive mechanism in a variety of cancers, notably aml. The regulation of cellular senescence involves several components, including s-phase kinase-associated protein 2 (skp2). Overexpression of skp2 has been extensively documented in aml, with prior studies underscoring its involvement in the negative modulation of cellular senescence. Nonetheless, the precise mechanism through which skp2 governs cellular senescence in aml remains to be clarified. Therefore, this study aims to explore the mechanisms involved in the senescence response at the transcriptional, posttranscriptional, and translational levels as a consequence of skp2 suppression in aml cells. It was hypothesized that skp2 prevents cellular senescence in aml cells. This hypothesis was tested through sirna-mediated skp2 knockdown in kasumi-1, thp- 1 and hl-60 aml cell lines.
| Item Type: | Thesis (PhD) |
|---|---|
| Subjects: | R Medicine > R Medicine (General) > R5-920 Medicine (General) |
| Divisions: | Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis |
| Depositing User: | Mr Hasmizar Mansor |
| Date Deposited: | 24 Jun 2026 00:46 |
| Last Modified: | 24 Jun 2026 00:46 |
| URI: | http://eprints.usm.my/id/eprint/64436 |
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