Mohamad, Khairunnisa (2025) Evaluation Of Treatment Outcomes And Prognostic Factors In Managing Children With Steroid Sensitive Nephrotic Syndrome In Malaysia. Masters thesis, Perpustakaan Hamzah Sendut.
![[img]](http://eprints.usm.my/style/images/fileicons/application_pdf.png) |
PDF
Download (665kB) |
Abstract
Steroid sensitive nephrotic syndrome (ssns) in children generally has a positive prognosis, yet a subset experiences frequent relapses or steroid dependent nephrotic syndrome (fr/sdns), posing management challenges. Steroids, mainly prednisolone, are the first-line treatment, with steroid sparing agents (ssas) reserved for ongoing relapses, steroid toxicity, or persistent steroid dependency. Despite evolving treatment protocols, studies on ssns management outcomes in malaysian children remain limited. Therefore, this study aimed to assess treatment outcomes and identify prognostic factors influencing fr/sdns development and the need for ssa. This retrospective multicentre cohort study followed 216 children with ssns for a median of 3.4 years (range 1.0–15.0). Among them, 58.8% developed fr/sdns, 27.3% had infrequent relapses, and 13.9% achieved sustained remission. The initial steroid protocol, either short or prolonged, did not influence fr/sdns risk (p=0.619). However, fr/sdns patients experienced earlier first relapses (median: 4.2 months, range: 1.0-37.7) and a higher incidence of steroid-related adverse effects (50.4%). A relapse within six months of diagnosis was strongly associated with fr/sdns development (adjusted odds ratio [aor] 7.04, 95% ci 3.53-14.02).
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica |
| Divisions: | Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis |
| Depositing User: | Mr Hasmizar Mansor |
| Date Deposited: | 19 Jun 2026 01:04 |
| Last Modified: | 19 Jun 2026 01:04 |
| URI: | http://eprints.usm.my/id/eprint/64402 |
Actions (login required)
 |
View Item |
