Yousif, Ibrahim M. Abdulbaqi Almalla (2025) Formulation And Evaluation Of Liquid Crystalline Nanostructures For The Pulmonary Delivery Of Docetaxel. PhD thesis, Perpustakaan Hamzah Sendut.
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Abstract
Lung cancer is the leading cause of cancer-related deaths worldwide. Docetaxel (dtx) is a widely used chemotherapeutic agent; however, its poor solubility, low bioavailability, and high systemic toxicity limit its therapeutic efficacy. Conventional intravenous formulations utilise ethanol and surfactants such as polysorbate 80 (tween 80®), which cause severe adverse effects, including nephrotoxicity and hypersensitivity. This underscores the need for targeted drug delivery to enhance dtx efficacy while minimising systemic toxicity. Pulmonary delivery via lipid-based nanoparticles, particularly liquid crystalline nanostructures (lcns), presents a non-invasive and efficient approach with improved patient compliance. This study aimed to develop and characterise inhalable dtx-loaded lcns for pulmonary delivery, optimising anticancer efficacy while potentially reducing adverse effects. Lcns were prepared via extrusion, ensuring minimal dispersed phase loss and structural integrity. Small-angle x-ray scattering (saxs) confirmed cubic internal nanostructures, validating extrusion as a scalable fabrication method. A series of four full factorial experiments yielded 40 formulations, of which 11 met the selection criteria of highest lipid content, smallest particle size (ps), and a polydispersity index (pdi) < 0.25. Dtx was loaded at 2, 5, and 10 mg/ml, with 5 mg/ml identified as optimal.
| Item Type: | Thesis (PhD) |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica |
| Divisions: | Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis |
| Depositing User: | Mr Hasmizar Mansor |
| Date Deposited: | 19 Jun 2026 01:00 |
| Last Modified: | 19 Jun 2026 01:00 |
| URI: | http://eprints.usm.my/id/eprint/64399 |
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