Mando, Zaynab (2025) Insights Into The Antidepressant Effects Of Centella Asiatica'S Triterpenoids In Unpredictable Chronic Stress Zebrafish Model: In Silico And In Vivo Studies. PhD thesis, Perpustakaan Hamzah Sendut.
![[img]](http://eprints.usm.my/style/images/fileicons/application_pdf.png) |
PDF
Download (396kB) |
Abstract
Depression is a debilitating mental disorder with high prevalence around the world. While current antidepressants have shown efficacy, they are limited by side effects, highlighting the need for novel therapies. Centella asiatica is a traditional medicinal herb recognised for its various neuropsychiatric benefits. The pentacyclic triterpenoids; asiatic acid and madecassic acid, and their related saponins; asiaticoside and madecasosside are the major constituents of c. Asiatica. Few pharmacological reports on the antidepressant activity of c. Asiatica’s triterpenoids biomarker are available, whereby the underlying mechanisms remain poorly understood. This work aims to investigate the potential antidepressant effects of the triterpenoids and their correlation with the serotoninergic system, hypothalamic-pituitary-adrenal (hpa) axis, immune response and brain endogenous metabolites. The antidepressant effect of c. Asiatica’s biomarkers on the serotoninergic system was evaluated via in silico approach.
| Item Type: | Thesis (PhD) |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica |
| Divisions: | Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis |
| Depositing User: | Mr Hasmizar Mansor |
| Date Deposited: | 09 Jun 2026 03:41 |
| Last Modified: | 09 Jun 2026 03:41 |
| URI: | http://eprints.usm.my/id/eprint/64335 |
Actions (login required)
 |
View Item |
