Yaakob, Nur Ain (2021) Study Of Red Cell Transfusion Practice Among Paediatric Oncology Patients At Hospital Usm. Masters thesis, Universiti Sains Malaysia.
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Abstract
INTRODUCTION: Blood transfusion has long been part of the supportive treatment for children with oncology. This study aims to look at the red blood cell (RBC) transfusion practice and its adverse effect on paediatric oncology patients at Hospital Universiti Sains Malaysia (HUSM). METHODS: This retrospective cohort study was conducted at HUSM. A total of 192 paediatric patients with haematological and solid tumour malignancies were enrolled. Demographic, clinical and transfusion data were collected and analysed. RESULTS: The prevalence of red blood cell transfusion among paediatric oncology patients is 82.3%. In contrast, the paediatric oncology group accounts for only 7.2% of the total transfused paediatric population at HUSM. Before the transfusion, the majority of patients had an average haemoglobin level of 6.8 g/dL and symptomatic anaemia. Transfusion reactions occurred at a rate of 6.3%, while red cell alloimmunisation occurred at a rate of 1.9%. There was no statistically significant association between transfusion reaction with patients’ demographic characteristics; disease category; total transfusion episodes and volume; antibiotic; chemotherapy; and pre-transfusion medication. CONCLUSION: Even though RBC transfusion is common in paediatric oncology, it was not the group with the highest recipient for RBC transfusion at HUSM. Due to the general patients’ immunocompromised state, there is a low incidence of alloimmunisation. The possibility of underdiagnosis of transfusion reaction must be considered. The existence of established protocols is critical in assisting clinicians in justifying blood transfusion decisions. Vigilant transfusion practise lowers the risk of adverse events in blood transfusion.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine |
| Divisions: | Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis |
| Depositing User: | NOR HASHIMY BIN ABDULLAH |
| Date Deposited: | 13 May 2026 01:29 |
| Last Modified: | 13 May 2026 01:29 |
| URI: | http://eprints.usm.my/id/eprint/64172 |
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