Zhang, Haolong (2025) Identification And Validation Of Hub Genes Involved In Atp-Induced Cell Death In The Pathogenesis Of Inflammatory Bowel Disease. Masters thesis, Perpustakaan Hamzah Sendut.
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Abstract
Extracellular adenosine triphosphate (eatp) plays a critical role in inflammatory bowel disease (ibd) as a key regulator of cell death processes. The p2x7 receptor, found on intestinal epithelial cells, is frequently implicated in cell death mechanisms involving eatp. However, the specific mechanisms of eatp-induced cell death and their connection to ibd remain unclear. Therefore, the primary objective of this study is to integrate data collection, bioinformatics analysis, and experimental validation to identify and confirm hub genes involved in eatp-induced cell death in the context of ibd. This approach combines computational and laboratory methods to produce reliable and high-confidence results. Not only does this approach enhance understanding of the molecular pathways involved in atp-induced cell death, but it also offers potential therapeutic targets for managing ibd. The experiment begins with data collection, focusing on acquiring relevant datasets and gene sets from public databases and scientific literature. For transcriptomic data, keywords such as "ibd" and "transcriptome" were used to search the geo database (gene expression omnibus, specify abbreviation).
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine > R Medicine (General) > R5-920 Medicine (General) |
| Divisions: | Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis |
| Depositing User: | Mr Hasmizar Mansor |
| Date Deposited: | 07 May 2026 02:27 |
| Last Modified: | 07 May 2026 02:27 |
| URI: | http://eprints.usm.my/id/eprint/64108 |
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