Rosli, Norlihayana (2025) Identification Of Novel Mutations In Non-Syndromic Skeletal Mandibular Prognathism In Malay Subjects: Insights From Whole Exome Sequencing And Inheritance Pattern. Masters thesis, Perpustakaan Hamzah Sendut.
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Abstract
Mandibular prognathism is a class iii skeletal base manifestation. It is characterised by a reverse overjet in the anterior teeth and a concave facial profile, leading to aesthetic concerns, misaligned bite, and speech issues. Genetic factors are believed to be the primary cause, yet the genetic basis of non-syndromic mandibular prognathism in the malay population remains largely unexplored. The problem lies in the varied genetic loci, candidate genes, and inheritance patterns observed across populations, implying that each ethnic group may possess distinct mutations and inheritance patterns associated with mandibular prognathism. This study aims to discover novel mutations, including the genes and loci, and to determine the inheritance pattern of non-syndromic mandibular prognathism in the malay subjects.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine > R Medicine (General) > R5-920 Medicine (General) |
| Divisions: | Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis |
| Depositing User: | Mr Hasmizar Mansor |
| Date Deposited: | 05 May 2026 00:56 |
| Last Modified: | 05 May 2026 00:56 |
| URI: | http://eprints.usm.my/id/eprint/64066 |
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