Rou, Khor Jia (2025) Gastroprotective And Antiulcer Activities Of Pomelo (Citrus Maxima) Leaf Extracts. Masters thesis, Perpustakaan Hamzah Sendut.
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Abstract
This study explores the potential gastroprotective effects and antiulcer activity of pomelo (citrus maxima) leaf extract against gastric disorders. Despite the traditional use of citrus maxima in various medicinal applications, scientific evidence on the gastroprotective effects of pomelo leaf extract is limited. The research aims to fill this gap by investigating the effectiveness of citrus maxima leaves in preventing and treating gastric ulcers. The study objectives include the development of a stability-indicating hplc method for identifying marker compounds, optimizing the extraction, and drying process, assessing phytochemical constituents, and evaluating gastroprotective effects using an in vivo rat model. This study successfully developed and validated a stability-indicating hplc- uv method for precise determination of rhoifolin in citrus maxima leaves extract. Among the tested leaves, which include young, old, fresh, and dried leaves, it was found that the most optimum leaves extract for gastroprotective therapeutics efficacy is dried old leaves as far as manufacturing and raw material handling are concerned.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica |
| Divisions: | Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis |
| Depositing User: | Mr Hasmizar Mansor |
| Date Deposited: | 29 Apr 2026 04:22 |
| Last Modified: | 29 Apr 2026 04:22 |
| URI: | http://eprints.usm.my/id/eprint/64024 |
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