Gu, Yanrong (2025) T Cell And Macrophage Interaction In Experimental Bleomycin-Induced Idiopathic Pulmonary Fibrosis. PhD thesis, Perpustakaan Hamzah Sendut.
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Abstract
Pulmonary fibrosis is a progressive and irreversible disease with poorly understood aetiology and high mortality rates. The cell interactions in immune regulation play a pivotal role in disease progression. While macrophages have been extensively studied in lung fibrosis models, their interactions with other cells, especially with T cells remain largely unknown. Particularly, the crosstalk between innate immunity and adaptive immunity is of great interest. The current study was performed to determine the effect of macrophages and T cells interaction on pulmonary fibrosis progression. Firstly, the increase and activation of T cells were validated in a mouse model of bleomycin (BLM)-induced pulmonary fibrosis. Then, the impact of T cells on disease progression was investigated using CD3e knockout (CD3e KO) T cell-deficient mice. Surprisingly, the absence of T cells resulted in markedly more severe lung fibrosis, accompanied by a significant increase in interstitial macrophages (IMs).
| Item Type: | Thesis (PhD) |
|---|---|
| Subjects: | R Medicine > R Medicine (General) > R5-920 Medicine (General) |
| Divisions: | Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis |
| Depositing User: | Mr Hasmizar Mansor |
| Date Deposited: | 29 Apr 2026 01:30 |
| Last Modified: | 29 Apr 2026 01:30 |
| URI: | http://eprints.usm.my/id/eprint/64015 |
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