Rumah, Muhammad Hayatuddeen (2024) Effect Of Murine Norovirus-3 (Mnv-3) Infection On Atherosclerosis Development In Macrophage Cell Lines And C57bl/6 Mice. PhD thesis, Perpustakaan Hamzah Sendut.
![[img]](http://eprints.usm.my/style/images/fileicons/application_pdf.png) |
PDF
Download (1MB) |
Abstract
Atherosclerosis, a chronic inflammatory disease, is characterized by lipid build-up in the arterial wall and regulated by innate and adaptive immune responses. Significant roles in the disease’s onset and progression are played by macrophages and various t-cell subsets. The effect of murine noroviruses-3 (mnv-3) infection on atherosclerosis development was investigated in this study using in vitro and in vivo models. In the in vitro model, atherosclerosis was induced by oxldl, whereas in the in vivo model, a cholesterol-rich diet was used to induce atherosclerosis in c57bl/6 mice. In the in vitro experiment, a reduction in atherosclerosis was observed in pre-infected raw 264.7 cells due to decreased tce , pro-inflammatory cytokine secretion (tnf-α, il-6, il-1β), and macrophage surface protein expression (cd88, cd36, cd11b) levels. Conversely, mnv-3 infection promoted atherosclerosis in post-infected raw 264.7 cells by elevating tce levels, boosting tnf-α, il-6, il-1β secretions, and promoting cd88, cd36, cd11b expression levels. Lastly, no significant alteration in atherosclerosis was observed in co-infected raw 264.7 cells, as tce levels, tnf-α, il-6, il-1β secretions, and cd88, cd36, cd11b expression levels were not significantly affected. In thp-1 derived macrophages, mnv-3 promoted atherosclerosis by boosting tnf-α, il-6, il-1β secretions and promoting cd88, cd36, cd11b expression levels.
| Item Type: | Thesis (PhD) |
|---|---|
| Subjects: | R Medicine > R Medicine (General) > R5-920 Medicine (General) |
| Divisions: | Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis |
| Depositing User: | Mr Hasmizar Mansor |
| Date Deposited: | 25 Feb 2026 01:18 |
| Last Modified: | 25 Feb 2026 01:18 |
| URI: | http://eprints.usm.my/id/eprint/63649 |
Actions (login required)
 |
View Item |
