Evaluating Drug-Drug Interactions, Polypharmacy, Their Association With Mortality And Assessing Quality Of Life Among Hemodialysis Patients In Libya

Gawdat, Rafadi Bilal B (2024) Evaluating Drug-Drug Interactions, Polypharmacy, Their Association With Mortality And Assessing Quality Of Life Among Hemodialysis Patients In Libya. PhD thesis, Perpustakaan Hamzah Sendut.

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Abstract

This research addresses the critical gaps in understanding drug-drug interactions, polypharmacy, and health-related quality of life among libyan hemodialysis patients, a population for which limited data exist. Given the high risk of adverse outcomes due to drug-drug interactions and polypharmacy in hemodialysis patients, the study aims to evaluate their prevalence and predictors, and to examine their association with in-hospital mortality. Additionally, the research explores the health-related quality of life of this population, identifying key determinants that influence the quality of life in end-stage renal disease patients, an area that remains underexplored in the libyan healthcare context. This study is divided into two parts. The first part presents a retrospective study aimed at identifying the prevalence and predictors of drug-drug interactions and polypharmacy in libya, as well as examining their association with in-hospital mortality. The second part involves a cross-sectional study conducted to assess health-related quality of life among hemodialysis patients and to identify the factors influencing health-related quality of life. The retrospective study revealed that the prevalence of drug-drug interactions among hemodialysis patients is71.1% and polypharmacy is 74.1%, while hyper-polypharmacy prevalence rate is 9.2%, respectively.

Item Type: Thesis (PhD)
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis
Depositing User: Mr Hasmizar Mansor
Date Deposited: 13 Feb 2026 01:22
Last Modified: 13 Feb 2026 01:22
URI: http://eprints.usm.my/id/eprint/63594

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