Saadon, Dr Nooraishah (2024) The Effect Of Fatty Meal, Milk And Water On The Sub- diaphragmatic Activity In Tc-99m Tetrofosmin Myocardial Perfusion Imaging. Masters thesis, Universiti Sains Malaysia.
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Abstract
Background: There are multiple methods available for diagnosing coronary artery disease (CAD), including myocardial perfusion imaging (MPI). One of the challenges to interpret MPI findings is the interfering sub-diaphragmatic activity with appropriate cardiac visualisation. Various methodologies were assessed in order to overcome this issue. A relatively common method is the consumption of fatty meals before proceeding with the scan. Nevertheless, consumption of high-fat meals may result in adverse effects for certain patients, in addition to incurring additional expenses. The aim of this study is to investigate the impact of consuming a high-fat meal, milk, or water before undergoing MPI and to aid in the interpretation of the results. Methods: A total of 150 patients (age 58.86 ± 12.05 years) were enrolled in this study. The patients were randomly divided into three groups. These patients underwent a two-day protocol of MPI. During the day of the pharmacological stress study, they were given a fatty meal. During the rest study, fifty the patients in Group 1 were given a fatty meal, fifty in Group 2 were given 350 ml of milk and fifty patients in Group 3 were given 350 ml of water. The study was double blinded for both patients and interpreters. Stress and rest MPI studies were performed for all patients and the sub-diaphragmatic activity was determined visually, and semi-quantitatively on the reconstructed images. Results: The difference between all groups, as determined by semi-quantitative and visual evaluations, is not statistically significant. Conclusion: The findings of this comparative study indicated that scans conducted after preparing fatty meal, milk, and water prior to MPI yielded similar interpretations and image quality.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis |
| Depositing User: | NOR HASHIMY BIN ABDULLAH |
| Date Deposited: | 12 Feb 2026 03:34 |
| Last Modified: | 12 Feb 2026 03:35 |
| URI: | http://eprints.usm.my/id/eprint/63585 |
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