Marimuthu, Sanggary (2025) Factors associated with non-initiation of tuberculosis preventive treatment among latent tuberculosis infection cases in Negeri Sembilan from 2022-2024 2022-2024. Masters thesis, Universiti Sains Malaysia.
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Abstract
Background: Tuberculosis Preventive Treatment (TPT) is essential in reducing the risk of progression from latent tuberculosis infection (LTBI) to active disease. However, the factors associated with the non-initiation of TPT have not been explored thoroughly. Objective: This study aimed to determine the proportion of LTBI patients who did not initiate TPT and to identify factors associated with non-initiation in Negeri Sembilan between 2022 and 2024. Methodology: A retrospective cross-sectional study was conducted involving 757 LTBI cases reported from January 2022 to December 2024. Data were extracted from the National Tuberculosis Registry system using a universal sampling method and analysed with SPSS software. Univariable and multivariable logistic regression analyses were performed to determine the factors significantly associated with non-initiation of TPT. Results: Overall, 9.3% of patients did not initiate TPT. Occupation emerged as a significant predictor; the “unemployed young” group (comprising students and children under five) had significantly higher odds of non-initiation compared to professionals (aOR = 3.52; 95% CI: 1.35,9.16; p = 0.010). The district of residence was also influential, with patients from Tampin having five times the odds of not initiating TPT compared to those from Seremban (aOR = 5.12; 95% CI: 2.59,10.11; p < 0.01), while residence in Jempol had lower odds (aOR = 0.10; 95% CI: 0.01,0.74; p = 0.024). In addition, foreign nationals were significantly more likely not to initiate treatment compared to Malaysian citizens (aOR = 3.83; 95% CI:1.65,8.85; p = 0.020). Conclusion: Occupation, nationality, and geographical location significantly influence the initiation of TPT among LTBI patients in Negeri Sembilan. These findings highlight the importance of centralised LTBI care, robust follow-up mechanisms, and tailored health education efforts to improve treatment uptake especially among high-risk group such as people living with HIV (PLHIV), contact of TB index cases, healthcare worker, prisoners and residents of nursing home.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | latent TB, TPT |
| Subjects: | R Medicine R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine > RC306-320.5 Tuberculosis |
| Divisions: | Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Kesihatan (School of Health Sciences) > Thesis |
| Depositing User: | Mr Abdul Hadi Mohammad |
| Date Deposited: | 11 Feb 2026 03:12 |
| Last Modified: | 24 Feb 2026 01:40 |
| URI: | http://eprints.usm.my/id/eprint/63562 |
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