Partheeban, Yugaashini (2025) Screening of the anti-proliferative effects of baicalein and carbon nanodot combination on hela cancer cells. Project Report. Universiti Sains Malaysia. (Submitted)
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Abstract
This study identifies the anti-proliferative effects of a novel combination therapy using baicalein, a flavonoid, and carbon nanodots (CDs) on HeLa cervical cancer cells. Baicalein, known for its potent anti-cancer properties, has shown limitations in clinical applications due to low bioavailability. Carbon nanodots, with their excellent biocompatibility, solubility, and drug delivery potential, were used as a carrier to enhance the therapeutic efficacy of baicalein. The study evaluated the anti-proliferative effects of the baicalein-carbon nanodot (Bai-CDs) combination in comparison to standalone treatments of baicalein, CDs, and cisplatin on HeLa cells using the MTT assay. Results demonstrated that the combination therapy significantly inhibited cell proliferation in a dose-dependent manner with the IC50 69.85 ± 4.145μg/ml and p-value less than 0.05. These findings highlight the potential of the Bai-CDs combination as a new therapeutic strategy for cervical cancer, providing enhanced bioavailability and targeted anti-cancer effects while minimizing adverse outcomes associated with conventional chemotherapy
| Item Type: | Monograph (Project Report) |
|---|---|
| Uncontrolled Keywords: | anti-proliferative |
| Subjects: | R Medicine R Medicine > RA Public aspects of medicine > RA440-440.87 Study and teaching. Research |
| Divisions: | Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Pergigian (School of Dental Sciences) > Monograph |
| Depositing User: | MUHAMMAD AKIF AIMAN AB SHUKOR |
| Date Deposited: | 21 Dec 2025 00:40 |
| Last Modified: | 29 Dec 2025 07:03 |
| URI: | http://eprints.usm.my/id/eprint/63407 |
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