Zaman, Shareezma Kamarul (2025) Understanding the role of nnav1.5 in breast cancer via sirna approach. Project Report. Universiti Sains Malaysia. (Submitted)
![[img]](http://eprints.usm.my/style/images/fileicons/application_pdf.png) |
PDF
Download (274kB) |
Abstract
Neonatal Nav1.5 (nNav1.5) plays a crucial role in the development and spread of breast cancer. This work highlights its potential as a biomarker and treatment target. The hallmarks of breast cancer, a cancer that is common around the world, are unchecked cell growth and metastasis. Targeted therapies are needed since metastasis is responsible for around 90% of cancer-related fatalities, despite the advancements in early identification and therapy. The study explored the molecular mechanisms underlying nNav1.5's role in the invasive property of breast cancer. In MDA-MB-231 cells, siRNA-mediated knockdown was used to assess its effect of nNav1.5 mRNA expression and metastatic behaviour, cell motility. Previous research results showed that nNav1.5 is substantially overexpressed in metastatic breast cancer cells relative to non-metastatic cells, which is associated with increased invasive and migratory capabilities. In this study, the potential role of nNav1.5 in the development of metastases was further supported by the significant decrease in cancer cell motility which siRNA-mediated silencing of nNav1.5. This study also supports nNav1.5 expression as a useful prognostic indicator for aggressive breast cancer subtypes, the triple-negative breast cancer. A solid basis for future research aiming at incorporating nNav1.5-targeted tactics into precision medicine frameworks is established by this work, which also contributes to our understanding of metastatic biology. These results could greatly improve patient survival and breast cancer care by tackling the crucial problem of metastasis
| Item Type: | Monograph (Project Report) |
|---|---|
| Uncontrolled Keywords: | breast cancer |
| Subjects: | R Medicine R Medicine > RC Internal medicine > RC254-282 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Kesihatan (School of Health Sciences) > Monograph |
| Depositing User: | MUHAMMAD AKIF AIMAN AB SHUKOR |
| Date Deposited: | 16 Dec 2025 04:21 |
| Last Modified: | 25 Feb 2026 02:50 |
| URI: | http://eprints.usm.my/id/eprint/63397 |
Actions (login required)
 |
View Item |
