Saidin, Nuraniessa Juliana (2025) The screening of alpinia purpurata ethanol extract for selective anticancer activity in vitro. Project Report. Universiti Sains Malaysia. (Submitted)
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Abstract
Cancer, including breast, cervical, and brain cancers, remains a major health challenge globally, requiring effective treatments. This study investigates the cytotoxic effects of Alpinia purpurata ethanol extract and tamoxifen on HeLa, MCF-7, DTBRG, and Vero cells using the MTT assay and qualitative phytochemical tests to evaluate their potential as anticancer agents. The results revealed that the A. purpurata ethanol extract exhibited significant cytotoxicity, with IC50 values of 18.19±1.5 μg/mL for HeLa, 158.70±1.1 μg/mL for MCF-7, 68.47±1.7 μg/mL for DTBRG, and 3.31±2.5 μg/mL for Vero cells. Tamoxifen, a well-established anticancer drug, demonstrated stronger cytotoxic effects, with IC50 values of 0.13±0.5 μg/mL for HeLa and 1.61±0.7 μg/mL for MCF-7 cells. However, tamoxifen exhibited higher toxicity to normal cells. In conclusion, Alpinia purpurata ethanol extract shows promising anticancer activity with selective toxicity towards cancerous cells, suggesting its potential for development as a safer alternative to tamoxifen
| Item Type: | Monograph (Project Report) |
|---|---|
| Uncontrolled Keywords: | anticancer, in vitro |
| Subjects: | R Medicine R Medicine > RC Internal medicine > RC254-282 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Kesihatan (School of Health Sciences) > Monograph |
| Depositing User: | MUHAMMAD AKIF AIMAN AB SHUKOR |
| Date Deposited: | 11 Dec 2025 03:49 |
| Last Modified: | 25 Feb 2026 02:41 |
| URI: | http://eprints.usm.my/id/eprint/63392 |
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