Evaluation of the effects of kaffir lime and lemon myrtle essential oils on the digestive vacuole of plasmodium falciparum

Zaki, Nor Alia Sofea Mohd (2025) Evaluation of the effects of kaffir lime and lemon myrtle essential oils on the digestive vacuole of plasmodium falciparum. Project Report. Universiti Sains Malaysia. (Submitted)

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Abstract

Malaria is a severe and fatal disease caused by Plasmodium spp. and remains one of the leading global causes of morbidity and mortality. The emergence of drug- resistance P. falciparum in various countries has necessitated an effort to discover new antimalarial drugs targeting different pathways. Medicinal plants have been a fundamental part of traditional medicine for centuries. Natural compounds extracted from these plants have shown great promise in serving as lead candidates for drug development. Despite this, research on the effects of kaffir lime and lemon myrtle essential oils on the digestive vacuole of P. falciparum remains largely unexplored. Therefore, this study aimed to fill this knowledge gap by investigating the antimalarial activity of kaffir lime and lemon myrtle essential oils. The antimalarial potential of the kaffir lime and lemon myrtle against the chloroquine-sensitive strain (3D7) of P. falciparum was assessed by using in vitro antimalarial assay. The kaffir lime and lemon myrtle essential oils demonstrated weak or no antimalarial activity with IC50 values of 150.6 μg/mL and 273.5 μg/mL, respectively. Additionally, the treatment with different concentrations of kaffir lime and lemon myrtle essential oil showed no changes on the digestive vacuole pH. This study revealed that the pH of the digestive vacuole treated with kaffir lime and lemon myrtle essential oils are stable and comparable to the untreated control. This suggests that these essential oils do not alters the digestive vacuole pH of P. falciparum

Item Type: Monograph (Project Report)
Uncontrolled Keywords: Malaria
Subjects: R Medicine
R Medicine > RA Public aspects of medicine
Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Kesihatan (School of Health Sciences) > Monograph
Depositing User: MUHAMMAD AKIF AIMAN AB SHUKOR
Date Deposited: 10 Dec 2025 02:32
Last Modified: 11 Dec 2025 03:19
URI: http://eprints.usm.my/id/eprint/63386

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