Karim, Siti Hafzan Abd (2021) Povidone-soaked Sutures versus Ordinary Sutures for reducing surgical site infection: randomise control trial study in general surgery cases of Hospital Universiti Sains Malaysia. Masters thesis, Universiti Sains Malaysia.
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Abstract
Povidone-soaked Sutures versus Ordinary Sutures for Reducing Surgical Site Infection: Randomise Control Trial Study in General Surgery Cases of Hospital Universiti Sains Malaysia Abstract Introduction Surgical suture materials are used in the closure of most wound types. The ideal suture should allow the healing tissue to recover sufficiently to keep the wound closed together once removed or absorbed. The suture material contributes to SSIs because 66% of SSIs are related to the incision. The coated surgical suture was implemented in 2002 and has been licensed and widely used. Povidone-iodine has been shown to kill methicillin-resistant Staphylococcus aureus and other antibiotic-resistant strains. Objective The general objective is to determine the efficacy of using a 3-minute povidone-soaked suture to reduce surgical site infection during wound closure. The specific objective is to measure the surgical site infection rate between the povidone-soaked suture and ordinary suture and determine the extent of intervention needed for surgical site infection in each group. Design/Participants/Criteria/Methodology This randomised control trial, single-blinded, fulfils inclusion criteria such as age over 12 years old, clean or clean-contaminated surgery, and scheduled for elective surgery. The randomisation sequence was computer-generated, and the allocation sequence was sealed in sequentially numbered and opaque envelopes. The code will determine whether the suture is povidone-soaked or an ordinary braided suture for wound closure. The patient’s well-being was assessed on day ten and day 30 via phone calls or messages that had been provided. Result 140 patients were randomised, and 136 patients were analysed between both groups. Their mean age was 50.80 years old, and their mean BMI was 25.04kg. SSIs occurred in the intention to treat group in 18 (13.2%) of the total 134 patients on D10 follow up in this study. The povidone-soaked suture group had a slightly higher proportion of infected wounds, the risk of getting infected was not significantly higher. The risk ratio of getting infected at D10 postoperative for povidone-soaked suture was 1.67 (95% CI=0.68, 4.04), and at D30 postoperative was 2.12 (95% CI=0.67, 6.71). Conclusion Povidone-soaked sutures do not reduce the occurrence rate of SSIs compared with ordinary sutures.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Suture, povidone |
| Subjects: | R Medicine R Medicine > RD Surgery |
| Divisions: | Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Thesis |
| Depositing User: | Mr Abdul Hadi Mohammad |
| Date Deposited: | 27 Jan 2026 07:34 |
| Last Modified: | 11 Feb 2026 04:13 |
| URI: | http://eprints.usm.my/id/eprint/62765 |
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