Chear, Nelson Jeng Yeou
(2024)
Studies On The Chemistry, Anticholinesterase Activity And Toxicity Of Mitragyna Speciosa (Kratom) Alkaloids.
PhD thesis, Perpustakaan Hamzah Sendut.
Abstract
Mitragyna speciosa (korth) havil. Is a medicinal plant native to malaysia,
traditionally used to treat pain, diabetes, hypertension, and drug addiction. It is also
consumed as a tonic beverage to enhance alertness, attention and working performance
among labourers and farmers. Most pharmacological activities documented for m.
Speciosa focus on opioid-related activities. Research on the potential therapeutic
effects of m. Speciosa on the cholinergic neurotransmission system is still scarce. Only
one study has reported the anticholinesterase activity of the methanol extract and
mitragynine prepared from thai m. Speciosa. Therefore, this study aims to identify
potential cholinesterase inhibitors from m. Speciosa using a bioassay-guided isolation
approach. A total of thirteen alkaloids were isolated and characterized from the
alkaloid extract using modern chromatographic techniques and spectroscopic methods.
The isolated alkaloids were mitragynine (87), speciociliatine (88), speciogynine (89),
mitraciliatine (90), paynantheine (91), corynantheidine (101), corynoxine (81),
corynoxine b (82), mitrafoline (125), mitragynine oxindole b (117), mitragynine
oxindole a (116), 17(z)-speciociliatine (146), and speciociliatine n-oxide (98). Two
of these alkaloids, 17(z)-speciociliatine (146) and speciociliatine n-oxide (98), are the
new compounds from m. Speciosa. Notably, 17(z)-speciociliatine (146) is the fourth
isomer of mitragynine (87), in addition to (88), (89) and (90).
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