Khan, Irfan Ullah
(2017)
Staging Of Chronic Kidney Disease Among Elderly Patients: A Comparison Between Cystatin C And Creatinine Based Estimated Glomerular Filtration Rate.
Masters thesis, Perpustakaan Hamzah Sendut.
Abstract
Chronic kidney disease (CKD) is a major public health problem worldwide.
Just like other parts of the world the prevalence of CKD is increasing in Malaysia
(9.07% in 2011). In routine clinical practice serum creatinine (Scr) is the most widely
used endogenous biomarker of renal function. However, literature review reveals that
creatinine concentration has been affected by age, gender, muscle mass and diet,
which may lead to over/under estimation of CKD. Cystatin C an endogenous
biomarker produced by all the nucleated cells at a constant rate has been reported to
be a more accurate kidney marker and better at estimating small changes in
glomerular filtration (GFR). Therefore, the current cross-sectional study at HUSM
was conducted with the aim to evaluate the sensitivity and specificity of cystatin C
and creatinine based eGFR equations in staging CKD using Chronic Kidney Disease
Epidemiology Collaboration combined (CKD-EPlcr-cys) equation as a reference.
Furthermore, we also evaluated the concordance and predictors of concordance
between Modification of diet in renal disease (MORD) and CKD-EPlcys equations in
staging CKD. A total of 300 connectively enrolled established elderly CKD patients
at the study site who met the eligibility criteria were included. Serum samples were
collected and analyzed for serum creatinine and serum cystatin C. eGFR was
calculated on the basis of CKD-EPlcr-cys, CKD-EPlcys, CKD-EPlcr and MDRD.
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