Ahmad, Mohd Aliff (2022) Prevalence and risk of infection in patients with diabetes following primary total knee arthroplasty: a global systematic review and meta-analysis of 120,754 knees. Masters thesis, Universiti Sains Malaysia.
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Abstract
INTRODUCTION Diabetes mellitus (DM) is a known risk factor for infection following total joint arthroplasty. This study looked at the prevalence and risk of infection in diabetic and non-diabetic patients who had primary total knee arthroplasty (TKA). METHODOLOGY PubMed, Scopus, Google Scholar, Web of Science, and Science Direct electronic databases were searched for studies published up to 21 April 2022. To compare the risk of infection between diabetic and non-diabetic subjects, a pooled prevalence, and a risk ratio (RR) with 95% confidence intervals (CIs) were used. This research has been registered with PROSPERO (CRD42021244391). RESULTS There were 119,244 participants from 18 studies, with a total of 120,754 knees (25,798 diabetic and 94,956 non-diabetic). We discovered that the risks of infection in diabetic patients were 1.84 times significantly higher than in non-diabetic patients. Infection was more common in diabetic patients (1.9%) than in non-diabetic patients (1.2%). In a subgroup analysis, the risks of developing deep surgical site infection (SSI) were 1.96 times higher in diabetic patients, but no significant difference when compared in superficial SSI. Prevalence of deep SSI was higher in diabetic (1.5%) than in non-diabetic (0.7%), but the prevalence of superficial SSI was lower in diabetic (1.4%) than in non-diabetic (2.1%). CONCLUSION Consistent with previous research, we found diabetes is a risk factor for infection following primary TKA. However, the risk is much lower than previously published data, indicating that other factors play a larger role in infection.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | diabetes, infection |
| Subjects: | R Medicine R Medicine > RC Internal medicine > RC648-665 Diseases of the endocrine glands. Clinical endocrinology |
| Divisions: | Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Thesis |
| Depositing User: | Mr Abdul Hadi Mohammad |
| Date Deposited: | 28 May 2025 07:52 |
| Last Modified: | 01 Jun 2025 07:46 |
| URI: | http://eprints.usm.my/id/eprint/62365 |
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