Zhang, Shenghui
(2024)
Preclinical Evaluation Of Mechanisms Underlying Chemotherapy-Induced Ovarian Dysfunction And The Restorative Potential Of Mesenchymal Stem Cells In Premature Ovarian Insufficiency.
PhD thesis, Universiti Sains Malaysia.
Abstract
Conventional chemotherapy, while effective in eliminating cancer cells, unfortunately, inflicts collateral damage on normal cells with heightened proliferative capacity, particularly causing ovarian toxicity. This study delves into elucidating the underlying mechanisms of chemotherapeutic drug-induced ovarian damage, aiming to pave the way for the development of fertility-preserving adjuncts for female patients undergoing conventional cancer treatment. In this context, mesenchymal stem cells-extracellular vesicles (MSC-EVs), as promising cell-free therapeutic agents, demonstrate notable advantages in addressing ovarian dysfunction. However, the precise mechanisms through which MSC-EVs ameliorate chemotherapy-induced ovotoxicity remain unclear. The primary objectives of this study are to elucidate the toxicity of chemotherapeutic drugs on the ovary, unravel the potential mechanisms leading to follicle loss, and investigate the therapeutic potential of Menstrual blood-derived endometrial stem cell (MenSC)-EVs transplantation in alleviating chemotherapy-induced ovarian dysfunction.
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