Jason, Chin Khee Chian
(2018)
Transcriptome Study Of
Salmonella Enterica Subspecies Enterica Serovar Typhi Biofilm.
PhD thesis, Universiti Sains Malaysia.
Abstract
Typhoid fever is an acute systemic infection of humans caused by Salmonella
enterica subspecies enterica serovar Typhi (S Typhi). During infection the bacteria
forms biofilm in the gallbladder to protect itself from the harsh environment of the
host. Biofilm formation has been associated with increased resistance towards
antibiotics and the host immune system, and promotes bacterial persistence.
However, the mechanism of biofilm formation is unknown. High-throughput
sequencing using the Illumina HiSeq 2500 platform was performed to study the
transcriptome of S. Typhi planktonic, intermediate and mature biofilm cells to
identify the genes involved in biofilm formation and to postulate the mechanism of
action. Planktonic S.
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