Khor, Boon Keat
(2019)
Neuroprotective Effect Of
Andrographispaniculata In Betaamyloid
Model Of Inflammation
And Oxidative Stress.
Masters thesis, Universiti Sains Malaysia.
Abstract
The extracellular accumulation and deposition of P-amyloidi-42 (Ap) plaques
in neuronal cells has been well accepted as one of the neuropathologic hallmarks of
Alzheimer disease. This misfolded protein cause activation of glial cells and increase
of reactive oxygen species (ROS) and inflammatory mediators in the brain, leading
to neuronal dysfunction and death. Studies suggested that phytochemicals found in
the plant may attenuate the toxicity and inflammation caused by Ap. In this study,
the neuroprotective potential of Andrographis paniculata standardised extracts and
its diterpenes was evaluated in the Ap model of inflammation and oxidative stress.
Three extracts, namely aqueous [AP(H2O)]» 50% ethanolic (50% EtOH) and 95%
ethanolic (95% EtOH) were prepared (yield of 25-30.5%) and standardised using the
major diterpenes, andrographolide (ADG), neoandrographolide (Neo) and 14-deoxy-
11,12-didehydroandrographolide (AP3).
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