Furqan Faisal, Sarah
(2019)
In Vitro Anti Cancer Properties Of
Thiadiazole Coumarin Derivatives
Against Colon Cancer.
Masters thesis, Universiti Sains Malaysia.
Abstract
Thiadiazole coumarin derivatives have been shown to be promising anti-cancer
agents. In this study, five different thiadoazole coumarin derivatives (TCDs) were
studied for their anticancer activity towards colorectal, breast and lung carcinoma. The
TCDs {(OCH3-TC 1), (H3CO-TC 2), (H3CO-TC 3), (Br-TC 4), & (OH-TC)} are
different in their structures. The compounds were tested for two important pathways of
carcinogenesis namely angiogenesis and apoptosis. Angiogenesis is a process of new
blood vessel development which is crucial for neoplastic tissues to obtain nourishment
for their growth and metastasis.
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