Mhd Rodzi, Nur Anis Raihana
(2024)
A Randomized, Double Blind, Placebo-Controlled Human Clinical Trial On The Effects Of Sacha Inchi (Plukenetia Volubilis L.) Oil Supplementation In Hyperglycaemia, Hypertension And Hyperlipidaemia Patients.
PhD thesis, Universiti Sains Malaysia.
Abstract
The incidence of hyperglycaemia, hypertension and hyperlipidaemia (3Hs)
have been prevalent in many developed and developing countries. Sacha Inchi oil (SIO) is a rich source of plant-based omega-3, 6, and 9 polyunsaturated fatty acids with promising health effects. However, the effects of SIO as complementary medicine among the 3Hs individuals are narrowly investigated. The present randomised, doubleblind, placebo-controlled human clinical trial aimed to explore the effects of SIO supplementation on (1) glycaemic control; (2) BPs; (3) lipid profiles; (4) inflammatory
status; (5) oxidative stress; (6) circulating arterial calcification biomarkers; (7)
anthropometry measurements; (8) quality of life; (9) mental health status; and (10)
compliancy and tolerability among 3Hs patients. Fifty-four (n=54) 3Hs patients were recruited from Specialist Day Care Clinic, Pusat Perubatan USM Bertam, and
randomised into two groups: the SIO group (n=27) (received 1000mg of SIO soft gel per day) or placebo group (n=27) (received 1000mg corn oil soft gel for 12 weeks).
Fasting blood samples were collected at baseline and post week-12 to assess clinical and laboratory biochemical markers.
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