Sakaran, Sharmila Sandra
(2016)
Diffusion tensor imaging (dti) and fibre
tractography of younger and older adults.
Project Report.
Universiti Sains Malaysia.
(Submitted)
Abstract
Diffusion Tensor Imaging (DTI) is promising method of advanced magnetic resonance
imaging (MRI) technique. DTI is able to characterize microstructural changes and
provide quantitative information about tissue properties. The information is in the form
of parameter indices e.g. apparent diffusion coefficient (ADC), fractional anisotropy
(FA) and visualization of neuron fibres through a particular technique called fibre
tractography. Few previous studies have reported degradation of neural fibres and its
effect on diffusion of water molecule in aging brain. The aim of this study is to compare
DTI and number of fibres of CC and CST fibre bundle between young and old healthy
subjects. Two main white matter fibre bundles in human being were observed which are
Corpus Callosum (CC) and Corticospinal tract (CST) regions. Using retrospective
method, two sets of DTI images of healthy female subjects that are a young adult aged
30 year old and old adult aged 56 year old were taken at Advanced Medical and Dental
Institute University Sains Malaysia (AMDI-USM), for one to one comparison study.
Region of interests were located in the CC and CST area. Comparison of ADC, FA and
number of fibres was made between young subject and old subject. No significaant
differences were observed in ADC and FA value between young and old subject. The
percentage of difference between both subject for ADC value in CC and CST are 0.06%
and 5% respectively. Whereas, the percentage difference in FA are 0.1% and 0.5%
respectively. However, fibre tractography showed lesser number of fibres in old subject
compared to young subject for both regions with percentage difference for CC is 6.28%
and for CST 100.8%. In conclusion, no differences found in ADC and FA value between young and old subjects. However, fibre tractography revealed reduced number
of fibres in old subject compared to young subject.
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