Abdul Wahab, Nurul Wahidah
(2019)
Characterization Of CTP Synthase In
Zebrafish (Danio Rerio).
Masters thesis, Universiti Sains Malaysia.
Abstract
CTPS is an enzyme that catalyzes the synthesis of cytidine triphosphate
(CTP), one of the four basic nucleotide triphosphates that make up DNA and RNA.
CTPS dysregulation has been implicated in many different diseases and cancers. It
was also shown previously that CTPS can form filamentous structures called
cytoophidia. This structure was found on yeast, fruit flies and human. Nevertheless
the mechanism behind cytoophidia formation is still vague. To date, there are no in
depth studies yet on characterizing CTPS on Danio rerio (zebrafish) and as there are
two CTPS genes in zebrafish i.e ctpsla and ctpslb utilizing zebrafish as model
organism can further help to understand the CTPS and its cytoophidia. In this studies,
the antibody staining results shows that in developing embryos, CTPS is
concentrated on the pronephric duct area and the notochord at the end tail area.
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