Nagaya, Devaki
(2018)
Association Analysis Of Single
Nucleotide Polymorphism Of Opioid
Dependence Genes Among Malay Males
In Malaysia.
PhD thesis, Universiti Sains Malaysia.
Abstract
Drug addiction is a chronic and relapsing disorder is associated with genetics.
There are many studies have been reported the roles of single nucleotide polymorphisms
(SNPs) with drug dependence and among those, twelve (12) candidate genes that were
associated with drug dependence will be. investigated in this study. The candidate genes
are OPRD1 (Delta Opioid Receptor), OPR.K1 (Kappa Opioid Receptor), COMT
(Catechol — O-Methyltransferase gene), PDYN (Prodynorphin), DRD4 (Dopamine
receptor D4), ABCB1(P glycoprotein), DUSP (Dual Specificity Phosphatase 27) and
rs 10494334. The goal of this study was to determine the frequencies of these SNPs
rsl042114, rs702764, rs 199774, rs 1022563, rs910080, rs737866, rs 10494334,
rsl800955, rsl 128503, rsl045642, and rs2032582 and to study their association with
opioid dependence in Malay males in Malaysian population.
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