Muhamad, Nor 'Atiqah (2016) Morphological improvements of hypertensive rats thoracic aorta & kidney with syzygium polyanthum. Project Report. Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia. (Submitted)
|
PDF
- Submitted Version
Download (9MB) | Preview |
Abstract
National Health and Morbidity Survey (2015) reported that the prevalence of hypertension in Malaysia for 18 years old and above is higher as compared to our neighboring countries and international standards. Among others, this can be attributed to poor compliance to synthetic antihypertensive drugs due to their side-effects. Hence, people nowadays are seeking the alternative herb-based treatment that is familiar to them. Syzygium polyanthum or “serai kayu” is one of the herbs eaten raw by Kelantanese. The leaves are traditionally used to reduce blood pressure in hypertensive patient. Previous study has shown the S.polyanthum leaves extract significantly reduced the blood pressure in hypertensive rats. The objective of this study is to determine the effects of oral methanolic extract of S.polyanthum leaves (MESP) on histopathology of spontaneous hypertensive rat’s (SHR) aorta and kidney. MESP was prepared by sonication process. The period of the study was 4 weeks (sub-acute) where 1 5 male SHR were equally divided into 3 groups: Group 1 (MESP 2000 mg/kg), Group 2 (Losartan 10 mg/kg), Group 3 as untreated SHR (negative control for hypertension). Five male nonnotensive Wistar Kyoto Rats (WKY) served as a negative control (Group 4). All rats were euthanized at the end of the study. Rat’s thoracic aorta and kidney were examined by hematoxylin and eosin (H&E) staining; also with scanning electron microscope (SEM). In aorta of MESP-treated, the tunica adventitia and smooth muscle layer (tunica media) of and Losartan-treated SHR’s aorta was near-normal condition. Similar improvements in aorta were also noted on SEM. As for kidney, in MESPtreated SHR and Losartan-treated showed well-preserved glomerulus and well capsulated of Bowman’s capsule in both H&E and SEM. In conclusion, oral administrations of Sygyzium polyanthum extract was able to improve the morphological changes in aorta and kidney that are associated with hypertensive changes suggesting that a promising alternative treatment for hypertension.
| Item Type: | Monograph (Project Report) |
|---|---|
| Uncontrolled Keywords: | Herbal medicine, hypertension |
| Subjects: | R Medicine R Medicine > RA Public aspects of medicine > RA440-440.87 Study and teaching. Research R Medicine > RC Internal medicine > RC666-701 Diseases of the circulatory (Cardiovascular) system |
| Divisions: | Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Kesihatan (School of Health Sciences) > Monograph |
| Depositing User: | Mr Abdul Hadi Mohammad |
| Date Deposited: | 23 Jun 2024 08:24 |
| Last Modified: | 04 Aug 2024 07:09 |
| URI: | http://eprints.usm.my/id/eprint/60740 |
Actions (login required)
 |
View Item |
