Manshor, Nurul Maizan
(2023)
Study Of Blood Pressure Lowering Effects Of Labisia Pumila (Blume) Merz Var. Alata Extracts And Its Mechanism Of Actions In Spontaneously
Hypertensive Rats.
PhD thesis, Universiti Sains Malaysia.
Abstract
Hypertension is major risk for cardiovascular complications such as stroke,
myocardial infarction, ischemic heart disease and cardiac failure. Herbal medicines is an
important element for possible alternative treatments or novel drug discovery for
hypertension. Traditionally, Labisia pumila (Blume) Merz var. alata was used in
maintaining women's health especially in the post-menstrual and post-partum’s
conditions. In this study, vasorelaxant effects of Labisia pumila (Blume) Merz var. alata
extracts on blood pressure of spontaneously hypertensive rats (SHR) were studied. Labisia
pumila (Blume) Merz var. alata were extracted sequentially in solvents with different
polarity. SHR were treated once orally daily for 28 days with Labisia pumila (Blume)
Merz var. alata petroleum ether extract (LPPET), chloroform extract (LPCHLOR),
methanol extract (LPMEOH) and water extract (LPWE) at the dose of 500 mg/kg/day.
The systolic blood pressure (SBP) was non-invasively measured in conscious SHR by tailcuff
method. The blood pressure lowering effects of Labisia pumila (Blume) Merz var.
alata and its mechanisms were further carried out in anaesthetised-SHR, pithed-SHR and
isolated aortic ring of SHR. Agonists and antagonists (L-NAME, indomethacin,
methylene blue, ODQ, atropine, hexamethonium, prazosin and propranolol) were used for
the mechanism studies.
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