Kamaruddin, Nur Mariam
(2023)
Defective Particle Surface On Zno And Its Influence On The Optical, Electronic And Toxicity Properties.
PhD thesis, Universiti Sains Malaysia.
Abstract
Chemotherapy, radiation, and surgery are the most common treatments for cancer in recent years. Cancer is a disorder marked by uncontrolled malignant cell proliferation. Although in theory, all these treatments should be very successful at destroying cancer cells, nonselective therapeutic techniques nevertheless carry several major risks. Recent research has shown that zinc oxide (ZnO) has the potential to overcome these side effects due to its high biocompatibility, ease of surface functionalization, ability to target malignancy, and drug transport capability. These benefits allow ZnO to be chosen as biocompatible and biodegradable platforms, as well as being investigated for cancer treatment. The main objective of this study is to investigate how surface modification via various annealing ambient affects the properties of ZnO structures and how they relate to breast cancer cell survival (MCF-7). The morphological, structural, electrical, and optical properties of three ZnO (i) as grown (ZnO-AG), (ii) oxygen annealed (ZnO-O2) and (iii) nitrogen annealed (ZnO-N2) samples were investigated. The general morphologies of ZnO samples comprise rods, plates, tripod, and drumlike structures, as well as irregular shapes. The ZnO had a diameter of 30-200 nm while thickness 90-400 nm. Electron spectroscopy imaging (ESI) revealed oxygen and zinc atoms (O: Zn) distribution on the ZnO samples. On the ZnO surface, ZnO-O2 had a greater O:Zn ratio while ZnO-N2 had a lower O:Zn ratio. At 700oC, there was more oxygen adsorption on the ZnO-O2 surface whereas there was more oxygen desorption on the ZnO-N2 surface. Surface conductivity is reduced by ZnO-O2, whereas surface conductivity is increased by ZnO-N2. The highly polycrystalline properties of the ZnO sample were revealed by the XRD measurement.
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