Razali, Nadiah
(2022)
Peripheral Antihypertensive Mechanisms Of Zing/Ber Officinale Var. Rubrumin Spontaneously Hypertensive Rats.
PhD thesis, Perpustakaan Hamzah Sendut.
Abstract
Hypertension has been associated with end-organ damage that may eventually
lead to stroke, heart, and renal failure. Blood pressure variability is possibly the most
important determining factor for the end-organ damage. Zingiber officinale var. rubrum
(ZOVR) (Halia bara) is a Malay traditional medicine claimed to have antihypertensive
effects. This study investigated the effects of ZOVR (250 mg/kg b.w) on vascular
responsiveness and reactivity in spontaneously hypertensive rats (SHRs) and the
mechanisms involved. SHRs were orally fed daily for 28 days with ZOVR extracts and
non-invasive systolic blood pressure, mean arterial pressure, heart rate and body weight
were measured. Vascular reactivity and responsiveness were assessed using isolated
aortic rings, anaesthetised non- and pithed rats, respectively. Appropriate agonists and
antagonists (L-NAME, indomethacin, methylene blue, atropine, glibenclamide,
hexamethonium, prazosin and propranolol) for the mechanism study were employed.
All three crude extracts of ZOVR significantly reduced the mean arterial pressure
(MAP) of SHRs in comparison or comparable with verapamil during the 28-day daily
oral feeding of ZOVR extracts, with petroleum ether extract (ZOP) produced the most
antihypertensive effect and selected for fractionation.
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