Tajuddin, Liza Sharmini Ahmad
(2015)
A study on the effect of arterial stiffness,
ocular perfusion pressure and genetics on
the severity and progression of glaucoma.
Project Report.
Pusat Pengajian Kesihatan.
(Submitted)
Abstract
Inadequate blood supply to the optic nerve head (ONH) has been implicated for glaucomatous damage
based on the vascular theory of glaucoma. Ocular perfusion pre^ure (OPP) is the balance of systemic
blood pressure and intraocular pressure (IOP). OPP is believecf play an important role in maintaining the
function of retinal nerve fiber layer (RNFL). Low OPP is believed to cause further damage to the RNFL.
There was significant association of low OPP with severity of glaucoma in this study. However, there was
no association with progression of glaucoma.Ocular perfusion may also be affected by the stiffness of the
vessels and endothelial dysfunction. There was significant association of endothelial dysfunction with
severity of glaucoma. Systemic arterial stiffness seem not to affect the severity of glaucoma. Susceptibility
genetic markers for glaucoma in Malay patients were also identified. ABCC5 was found to significantly
associated with PACG in Malay patients. There was several markers that reached genome wide
association significant in Malay patients with POAG.
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