Tan, Aik Sian
(2022)
Synthesis, Characterization Of 1,3-Diarylpropenes And Tricyclic Indolines And The Cytotoxic Activities Of 1,3-Diarylpropenes.
Masters thesis, Universiti Sains Malaysia.
Abstract
Alkaloids are crucial nitrogen-containing compounds that exhibit diverse biological and pharmaceutical activity, regardless of the compound scaffold. Accordingly, it drives the synthesis of amido 1,3-diarylpropene and 6-5-4 tricyclic
indoline under the alkaloid class, potentially the chemotherapeutic agents for cancer treatment. In the first study, forty (40) 1,3-diarylpropene derivatives, designed
analogs of stilbenoids and dihydrostilbenoids, were synthesized by the palladiumcatalyzed reactions of 2-amidoiodobenzene derivatives with either estragole or
eugenol.
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