Isuparan, Dinishkumari
(2012)
Anti-inflammatory activity
of centella asiatica.
Project Report.
Universiti Sains Malaysia.
(Submitted)
Abstract
Centella asiatica (C.asiatica) is a member of a tropical plant family, traditionally used as anti-inflammation and for wound healing. Macrophage plays a primary role in innate macrophage cells stimulated with the plant extracts was initially investigated by MTT
cell proliferation assay and the anti-inflammatory activity of C.asiatica was determined
by measuring its effect on the H2O2 and NO production by the stimulated macrophage
cells. The data were analyzed using ANOVA and Tukey’s post hoc test. The result
showed that the methanolic leaves extract of the plant enhances the highest proliferation
of the J774A. 1 macrophage cell at 150 pg/mL. It was also found that the extract has a
significant anti-inflammatory effect in terms of cell proliferation, suppressing NO and
H2O2 production in concentration-dependent manner as compared to the control groups.
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