Ali, Niswathul Haania Zain
(2009)
Preliminary study: effect of 95% ethanol extract of senna
auriculata flower on streptozotocin- induced diabetes rats.
Project Report.
Universiti Sains Malaysia.
(Submitted)
Abstract
Diabetes mellitus is a disease of lifestyle which was observed to be more common in the
upper classes where they consume more unhealthy food and for this reason diabetes
mellitus is called rich man's disease and it has a vast impact on global burden of
mortality. Data published in journal showed that both of the aqueous and ethanol extract
of Senna auriculata (SA), have strong anti-hyperglycemic effect in the short term to
reduce blood glucose level in STZ- induced diabetic rats. The main objective of this
study is to evaluate the effect of 95 % ethanol extract of Senna auriculata prepared via
rotary evaporation method on streptozotocin (STZ) - induced diabetic male rats. In this
study, Sprague Dawley male rats of body weighed 130-180 grams were selected and
randomly assigned to 6 groups. The diabetic negative control rats were given orally
carboxyl methyl cellulose (CMC) 2% as vehicle and positive control rats were given
15mg/kg metformin also orally. While the rats in treatment group were given 95 %
ethanol extract of Senna auriculata via oral route at doses 50,100 and 200 mg/kg daily
respectively for 25 days. The rats body weight, fasting blood glucose and physical
changes were observed throughout the study period. At the end of the study period the
blood glucose level were measured before the rats sacrificed after anesthetized. The rats'
pancreas was taken for histological examination. The fasting blood glucose were not
significantly different (p>0.005) in SA treated diabetic group compared to diabetic
control group after treatment for 25 days with 95 % ethanol extract of SA. Based on the
data produced it shows that 95 % ethanol extract of Senna auriculata flower have no
anti-hyperglycemic effect on STZ- induced diabetic male rats.
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