Hirman, Melissa Mohammad
(2022)
Development And Evaluation Of A
Guideline On Potassium Chloride
Intravenous Supplementation:
Effectiveness, Safety And Cost
Implications.
PhD thesis, Universiti Sains Malaysia.
Abstract
The concentrated potassium chloride injection used in intravenous
supplementation of potassium in hypokalemia is associated with risks of
hyperkalemia and medication error. This study aimed to develop a guideline on
potassium chloride intravenous supplementation with the emphasis of using
premixed formulations and evaluate its safety, effectiveness and cost implications. In
Phase I of this study, a nationwide survey was conducted among 207 Malaysian
hospital physicians. The findings suggested that there were variations in Malaysian
physician’s prescribing practice of intravenous potassium supplementation in the
treatment of hypokalemia. Data analysis revealed different physicians background
resulted in different prescribing practices which may be due to the complexity of
patient’s clinical conditions and medications. This poses a challenge for prescribers
to treat hypokalemia and supports the need to have a practical or general guideline
that can be used under different clinical conditions. This survey also revealed that
Malaysian physicians favoured premixed potassium chloride formulations where
physicians find it would ease usage and is safer for the patient. In Phase II of this
study, a guideline with emphasis of premixed formulations was developed and
implemented in a private hospital.
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