Aminuddin, Aiza Izyani
(2015)
Comparison of antimicrobial activity of crude ethanolic
extracts of five different plants against acne-inducing
bacteria.
Project Report.
Universiti Sains Malaysia.
(Submitted)
Abstract
Acne vulgaris is defined as a typical skin disorder among adolescence, causing
inflammation of pilosebaceous follicle which is characterized by comedones, papules,
pustules, cysts, nodules and often scars in face, neck, upper trunk and also arms. Propionibacterium acnes and Staphylococcus epidermidis have been recognized as a causal factor in acne formation. This study was conducted to compare the antimicrobial
activity of five plant extracts of Piper belle, Aloe vera, Solanum lycopersicum,
Cinnamomum zeylanicum and Cucumis sativus against P. acnes and 5. epidermidis. The
antimicrobial activity of five ethanolic plant extracts were investigated against the two
acne-inducing bacteria using well diffusion and minimum inhibitory concentration (MIC)
method. The well diffusion method result revealed that the ethanolic extracts of Piper
betle, Aloe vera, Solanum lycopersicum, Cinnamomum zeylanicum and Cucumis sativus
showed mean of inhibition zone diameter of 29.0 mm, 7.7 mm, 10.7 mm, 13.9 mm and
11.5 mm respectively against P. acnes bacteria and mean of inhibition zone diameter of
32.0 mm, 30.7 mm, 13.0 mm, 14.3 mm and 15.3 mm respectively against S. epidermidis
bacteria. The mean value of MIC against P. acnes for Piper betle extract and
Cinnamomum zeylanicum extract showed 39.06 mg/ml and 2.45 mg/ml respectively.
Whereas the mean value of MIC of all five ethanolic extracts of Piper betle and Aloe
vera, showed 2.45 mg/ml dan 78.13 mg/ml respectively. Meanwhile, the other ethanolic
extracts of Solanum lycopersicum, Cinnamomum zeylanicum and Cucumis sativus against
S. epidermidis bacteria showed 39.06 mg/ml. This suggests that Piper betle and
Cinnamomum zeylanicum extracts have showed the most effective antimicrobial effects
against acne-inducing bacteria. However, all of the ethanolic extracts were found to have
potency against acne-inducing bacteria which can be further evaluated in animal and
clinical research that can be used as an alternative treatment of acne commercially.
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