Zulazmi, Nurul Atiqah
(2013)
Hypotensive effect of aqueous and methanolic extracts
from syzygium polyanthum (wight) walp leaves on the
evaluation of nitric oxide pathway - an in vivo approach.
Project Report.
Universiti Sains Malaysia.
(Submitted)
Abstract
Syzygium polyanlhum (Serai kayu) is one of the traditional herbs (ulam) that eaten
freshly by Malaysian and traditionally used as a medicine for hypertension, stroke,
diabetes, hypercholesterolemia, cataracts, rashes, itchy and sore stomach. Previous
studies have established the biological profile and phytochemical analysis of S.
polyanthum that contain anti-hypertensive associated compounds. Even though this
plant has known to have potential in the treatment of hypertension but the
pharmacological mechanism of it is still unclear. In this research, we want to determine
the cardiovascular effects of S. polyanthum extracts on blood pressure of anaesthetised
rat and the involvement of nitric oxide system in the hypotensive effect. S', polyanthum aqueous extract (AESP) was prepared by freezed-dried. The residue obtained was extract in Soxhlet extractor and successively fractionated using methanol to obtain the
methanol extract (Meth-AESP). Both of the extracts were studied by administered
through the left jugular vein of anaesthetised rat and the blood pressure is recorded
through the cannulated right common carotid artery. Both Meth-AESP and AESP (100
mg/kg) significantly reduced the rat’s mean blood pressure (MBP) (p<0.001). With the addition of L-NAME (20 mg/kg), the hypotensive response of Meth-AESP was significantly reduced (p<0.001). However, L-NAME did not affect the hypotensive
response of AESP (p>0.05). We concluded that that hypotensive mechanism of Meth-
AESP is likely mediated through the involvement of nitric oxide system.
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