Ahmad, Noor Ashikin
(2015)
The effect of dose calculation algorithms on the normal tissue complication probability values of thoracic cancer.
Project Report.
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia.
(Submitted)
Abstract
Purpose: To identify the effect of dose calculation algorithms on the Normal Tissue
Complication Probability values of thoracic cancer.
Materials and Methods: NTCP
values from BIOPLAN software is calculated based on standard DVH data. Dose
distributions of treatment plans are calculated by using two different algorithms of
Oncentra Masterplan (OMP) treatment planning system (TPS) which are Collapse Cone
and Pencil Beam. Four treatment plans are created and DVHs are evaluated based on
criteria of acceptance level. NTCP values for thorax plan one and two are evaluated by
using different algorithm.
Results: The coverage of the target volume for all treatment
plans has achieved the desired isodose for at least 90% of isodose at 1 00% of volume.
Collapsed cone shows better calculation in three beam but pencil beam is better in 5
beams calculation. The NTCP values of the LKB model are slightly higher than RS
model for both cases even though using different kind of algorithm.
Conclusions: There
is no difference between pencil beam and collapsed cone algorithms in term of NTCP
values. NTCP values are due to physical and biological effects. Mathematically, both
treatment plans have higher probability to develop the complication but the numbers in
this paper are not wholly based on clinical or even experimental data. It may due to
patient-related factors, patient history or the modalities used in treatment delivery.
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