Preliminary study on the effects of winter melon (benincasa hispida) on glycemic profiles: In vivo test on streptozotocin sprague-dawley rats

Geduin, Florance (2014) Preliminary study on the effects of winter melon (benincasa hispida) on glycemic profiles: In vivo test on streptozotocin sprague-dawley rats. Project Report. Universiti Sains Malaysia. (Submitted)

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Abstract

Benincasa hispida (BH) or known as Winter Melon is a widely used vegetable in tropical countries and has been used to control diabetes traditionally among the citizen, particularly among the Asian people. Different parts of the BH were shown to have hypoglycemic and anti-diabetic effects. However, less study was done to study the hypoglycemic and antidiabetic properties of the flesh of BH. The hypoglycemic effects of the extract were studied on normal rats. Results showed that blood glucose level reduced by 14.2% during fasting blood glucose test. During oral glucose tolerance test (OGTT) in diabetic rats, blood glucose level reduced by 10.5%. The anti-diabetic effect were studied in Streptozotocin (STZ)- induced diabetic animals by comparing the effect of different aqueous extract doses on blood glucose levels in rats during OGTT and using the effective dose of extract (250 mg/kg daily) for 28 days in diabetic rats. The change in fasting blood glucose, body weight, urine sugar and HbAlc level were monitored. The dose of 250 mg/kg was found to be an effective dose as it produced a fall of 17.8% in blood glucose level during OGTT in diabetic rat. After four weeks of treatment, the blood glucose level reduced by 29% and the body weight increased by 36.7%, compared to diabetic rats without treatment. The HbAlc level produced a fall of 7.3% but urine sugar showed no improvement after four weeks. The Benincasa hispida extract has not significantly improved the glycemic profile of the STZ-induced diabetic rats. However, it is shown to help improving the glycemic profile if the baseline blood glucose level is below 20 mmol/l.

Item Type: Monograph (Project Report)
Uncontrolled Keywords: Benincasa hispida, Aqueous extract; Diabetes mellitus; Anti-diabetic effect; Hypoglycemic effect; Streptozotocin
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Kesihatan (School of Health Sciences) > Monograph
Depositing User: Mr Husnan Budin
Date Deposited: 02 May 2023 08:19
Last Modified: 02 May 2023 08:19
URI: http://eprints.usm.my/id/eprint/57780

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