Manogaran, Manimegalai
(2016)
Analysis Of Phytochemicals,
Antioxidant And Antihyperlipidemic
Activities Of Methanolic And Aqueous
Extracts Of Various Parts Of Garcinia
Mangostana.
Masters thesis, Perpustakaan Hamzah Sendut.
Abstract
Garcinia mangostana is a tropical plant found commonly in South East Asia.
This plant possesses anti-inflammatory, antibacterial, antiulcer, antiseptic effects and
showed prevention against oxidative damage of low-density lipoprotein cholesterol
(LDL-C). The present study aimed to evaluate the antioxidant and antihyperlipidemic
activities as well as phytochemical analysis of methanolic and aqueous extracts of
various parts of leaves of G. mangostana, namely leaves, stem, bark, hull, petals,
stalk, seed and flesh. The highest phenolic content was found in methanolic (41.74
ug GAE/g) and aqueous (11.29 ug GAE/g) extracts of leaves. Leaves extracts also
showed highest flavonoid content of 31.80 ug GAE/g in methanolic and 19.48 ug
GAE/g in aqueous extracts. For ferric reducing antioxidant power (FRAP), both
methanolic and aqueous extracts of leaves showed most potent activity ofO.4S ± 0.01
urnol Fe2+/g and 0.39 ± 0.09 umol Fe2+/g respectively while u-mangostin possessed
low FRAP activity compared to the extracts. Methanolic extract of stalk showed
highest 2,2-diphenyl-l-picrylhydrazyl (DPPH) radical scavenging activity with ECso
of 3.36 ± 0.52 ug/ml, while aqueous extract of leaves showed ECso of 3.21 ± 0.57
J.1g/mL compared to 0.- mangostin which had ECso of 4.03 ± 0.87 ug/ml., For 2,2-
azinobis (3-ethyl- benzothiazolin-6-sulfate acid) (ABTS) radical scavenging activity,
methanolic extract of stem and aqueous extract of leaves showed highest activity
with ECso of 0.78 ± 0.45 J.1g/mL and 0.81 ± 0.37 ug/ml., respectively plus 0.mangostin
had ECso of 2.88 ± 0.55 J.1g/mL.
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