Ramli, Muhammad Azrul Hafizi
(2013)
A study on the prevalence of Miltenberger blood group (GP. Mur) of antigens and antibodies among blood donors and
patients with different blood group in Hospital Universiti
Sains Malaysia (HUSM).
Other.
Universiti Sains Malaysia.
(Submitted)
Abstract
The MNS system was the second blood group system discovered and at least 16 of the
46 antigens in the MNS system result from genetic recombination, producing a hybrid
glycophorin. The Mi (III) phenotype of the Miltenberger subsystem (GP. Mur) is one of
hybrid glycophorin produced by genetic recombination of MNS system. The incidence
of this hybrid glycophorin was highest in the East Asian populations and the antibodies
developed were immunogenic especially IgG type which can cause hemolytic
transfusion reaction (HTR), hemolytic disease of newborn and fetal (HDNF) and
hydrops fetalis. The aim of the study was to detect the prevalence of anti-Mur and anti-
MUT among patients and GP. Mur antigen in blood donors (healthy individuals) with
different blood group in Hospital Universiti Sains Malaysia (HUSM). Blood samples
from 27,322 patients with different blood group were screened by standard serological
method for the anti Mi (HI) antibody from September 2012 to March 2013 while 80
blood donors with different blood group were selected to detect GP. Mur phenotype by
serological method. Fifty-seven percent of donors were Malay while others were
Chinese. Anti-Mi (III) antibody were detected in 0.3 % of both antenatal and general
patients. Out of 83 patients, 15.7 % were positive for anti-Mur/MUT antibodies while
others were diagnosed as possible of other anti-Mi (HI) antibodies. Based on blood
group, 18.2 % of patients from A blood group were positive for anti-Mur/MUT
antibodies while 20.0 %, 8.7 % and 15.4 % were detected from B, O and AB blood
group. For GP. Mur phenotype, 5.0 % of Malay blood donors were detected to have GP.
Mur antigen while only 1.3 % was identified in Chinese blood donors. Only 5 % of
Malay blood donors from each A and O blood group were GP. Mur positive while 10 % of Malay and 5 % of Chinese have GP. Mur antigen in AB blood group. Based on the
findings that GP. Mur antigen were higher in Malay blood donors and with many
reports of clinical problems associated with the anti-Mi (III) antibody, it is warranted that the GP Mur red cells be included in screening panels for group and screen procedures in our hospitals.
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